Uncovering the Role of Hydrophobic Residues in Cytochrome P450−Cytochrome P450 Reductase Interactions
نویسندگان
چکیده
منابع مشابه
Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions.
Cytochrome P450 (CYP or P450)-mediated drug metabolism requires the interaction of P450s with their redox partner, cytochrome P450 reductase (CPR). In this work, we have investigated the role of P450 hydrophobic residues in complex formation with CPR and uncovered novel roles for the surface-exposed residues V267 and L270 of CYP2B4 in mediating CYP2B4--CPR interactions. Using a combination of f...
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Plants and herbivorous insects interact at the most fundamental of levels. With few exceptions, in the battle waged daily between these two groups of organisms, one serves as food source, the other as consumer. From a plant’s perspective, success in this interaction is measured by its ability to defend itself from devastation by insect feeding. From an insect’s perspective, success is measured ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2011
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi1020748